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Millepertuis - Les 5 PILIERS

Millepertuis

Hypericum perforatum
vendredi 11 janvier 2008
par  L. Berthier
popularité : 2%

Le millepertuis est bien connu des homéopathes car c’est un remède d’urgence en particulier pour les traumatismes des nerfs : plaies déchiquetées des extrémités. Mais cette plante faisait partie de l’arsenal thérapeutique de la Grèce et Rome antiques. Aujourd’hui les laboratoires utilisent le millepertuis pour ses vertues antidépressives.

Indications traditionnelles :
- usage externe : cicatrisation des plaies, brûlures, traumatismes musculaires.
- usage interne :
— parasitose intestinale,
— troubles respiratoires (asthme, bronchites)
— troubles digestifs : gastrite, dyskinésie biliaire
— troubles articulaires : rhumatismes, goutte.
— psychiatrie : syndrome dépressif[[certains laboratoires allèguent un effet similaire aux antidépressifs modernes)

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Cabrelle A, Dell’aica I, Melchiori L, Carraro S, Brunetta E, Niero R, Scquizzato E, D’Intino G, Calz L, Garbisa S, Agostini C. Free Full Text Hyperforin down-regulates effector function of activated T lymphocytes and shows efficacy against Th1-triggered CNS inflammatory-demyelinating disease. J Leukoc Biol. 2007 Oct 18 ; [Epub ahead of print] PMID : 17947392 [PubMed - as supplied by publisher] 2 : Related Articles, Links Butterweck V, Schmidt M. Abstract St. John’s wort : role of active compounds for its mechanism of action and efficacy. Wien Med Wochenschr. 2007 ;157(13-14):356-61. Review. PMID : 17704987 [PubMed - indexed for MEDLINE] 3 : Related Articles, Links Kraft K. Abstract [New developments in hypericum extracts : data on efficacy and interactions] Wien Med Wochenschr. 2007 ;157(13-14):284-7. Review. German. PMID : 17704973 [PubMed - indexed for MEDLINE] 4 : Related Articles, Links Chung DJ, Kim HY, Park KH, Jeong KA, Lee SK, Lee YI, Hur SE, Cho MS, Lee BS, Bai SW, Kim CM, Cho SH, Hwang JY, Park JH. Free Full Text Black cohosh and St. John’s wort (GYNO-Plus) for climacteric symptoms. Yonsei Med J. 2007 Apr 30 ;48(2):289-94. PMID : 17461529 [PubMed - indexed for MEDLINE] 5 : Related Articles, Links Anghelescu IG, Kohnen R, Szegedi A, Klement S, Kieser M. Abstract Comparison of Hypericum extract WS 5570 and paroxetine in ongoing treatment after recovery from an episode of moderate to severe depression : results from a randomized multicenter study. Pharmacopsychiatry. 2006 Nov ;39(6):213-9. PMID : 17124643 [PubMed - indexed for MEDLINE] 6 : Related Articles, Links Kasper S, Anghelescu IG, Szegedi A, Dienel A, Kieser M. Free in PMC Superior efficacy of St John’s wort extract WS 5570 compared to placebo in patients with major depression : a randomized, double-blind, placebo-controlled, multi-center trial [ISRCTN77277298]. BMC Med. 2006 Jun 23 ;4:14. PMID : 16796730 [PubMed - indexed for MEDLINE] 7 : Related Articles, Links Rudolf GA, Zeller K. Abstract [Highly dosed St. John’s wort extract improves quality of life] MMW Fortschr Med. 2004 Aug 5 ;146 Suppl 2:77-80. German. PMID : 16739363 [PubMed - indexed for MEDLINE] 8 : Related Articles, Links Wurglics M, Schubert-Zsilavecz M. Abstract Hypericum perforatum : a ’modern’ herbal antidepressant : pharmacokinetics of active ingredients. Clin Pharmacokinet. 2006 ;45(5):449-68. Review. PMID : 16640452 [PubMed - indexed for MEDLINE] 9 : Related Articles, Links Dean AJ. Abstract Natural and complementary therapies for substance use disorders. Curr Opin Psychiatry. 2005 May ;18(3):271-6. PMID : 16639151 [PubMed] 10 : Related Articles, Links Gastpar M, Singer A, Zeller K. Abstract Comparative efficacy and safety of a once-daily dosage of hypericum extract STW3-VI and citalopram in patients with moderate depression : a double-blind, randomised, multicentre, placebo-controlled study. Pharmacopsychiatry. 2006 Mar ;39(2):66-75. PMID : 16555167 [PubMed - indexed for MEDLINE] 11 : Related Articles, Links Stavropoulos NE, Kim A, Nseyo UU, Tsimaris I, Chung TD, Miller TA, Redlak M, Nseyo UO, Skalkos D. Abstract Hypericum perforatum L. extract - novel photosensitizer against human bladder cancer cells. J Photochem Photobiol B. 2006 Jul 3 ;84(1):64-9. Epub 2006 Mar 15. PMID : 16540336 [PubMed - indexed for MEDLINE] 12 : Related Articles, Links Uebelhack R, Blohmer JU, Graubaum HJ, Busch R, Gruenwald J, Wernecke KD. Abstract Black cohosh and St. John’s wort for climacteric complaints : a randomized trial. Obstet Gynecol. 2006 Feb ;107(2 Pt 1):247-55. PMID : 16449108 [PubMed - indexed for MEDLINE] 13 : Related Articles, Links Schulz V. Abstract Safety of St. John’s Wort extract compared to synthetic antidepressants. Phytomedicine. 2006 Feb ;13(3):199-204. Epub 2005 Nov 2. Review. PMID : 16428030 [PubMed - indexed for MEDLINE] 14 : Related Articles, Links Venkataramanan R, Komoroski B, Strom S. Abstract In vitro and in vivo assessment of herb drug interactions. Life Sci. 2006 Mar 27 ;78(18):2105-15. Epub 2006 Jan 19. Review. PMID : 16427092 [PubMed - indexed for MEDLINE] 15 : Related Articles, Links Randløv C, Mehlsen J, Thomsen CF, Hedman C, von Fircks H, Winther K. Abstract The efficacy of St. John’s Wort in patients with minor depressive symptoms or dysthymia—a double-blind placebo-controlled study. Phytomedicine. 2006 Mar ;13(4):215-21. Epub 2006 Jan 19. PMID : 16423519 [PubMed - indexed for MEDLINE] 16 : Related Articles, Links Kobak KA, Taylor LV, Bystritsky A, Kohlenberg CJ, Greist JH, Tucker P, Warner G, Futterer R, Vapnik T. Abstract St John’s wort versus placebo in obsessive-compulsive disorder : results from a double-blind study. Int Clin Psychopharmacol. 2005 Nov ;20(6):299-304. PMID : 16192837 [PubMed - indexed for MEDLINE] 17 : Related Articles, Links Fava M, Alpert J, Nierenberg AA, Mischoulon D, Otto MW, Zajecka J, Murck H, Rosenbaum JF. Abstract A Double-blind, randomized trial of St John’s wort, fluoxetine, and placebo in major depressive disorder. J Clin Psychopharmacol. 2005 Oct ;25(5):441-7. PMID : 16160619 [PubMed - indexed for MEDLINE] 18 : Related Articles, Links Gastpar M, Singer A, Zeller K. Abstract Efficacy and tolerability of hypericum extract STW3 in long-term treatment with a once-daily dosage in comparison with sertraline. Pharmacopsychiatry. 2005 Mar ;38(2):78-86. PMID : 15744631 [PubMed - indexed for MEDLINE] 19 : Related Articles, Links Sánchez-Mateo CC, Bonkanka CX, Prado B, Rabanal RM. Abstract Antidepressant properties of some Hypericum canariense L. and Hypericum glandulosum Ait. extracts in the forced swimming test in mice. J Ethnopharmacol. 2005 Mar 21 ;97(3):541-7. PMID : 15740893 [PubMed - indexed for MEDLINE] 20 : Related Articles, Links Farabaugh A, Mischoulon D, Fava M, Wu SL, Mascarini A, Tossani E, Alpert JE. Abstract The relationship between early changes in the HAMD-17 anxiety/somatization factor items and treatment outcome among depressed outpatients. Int Clin Psychopharmacol. 2005 Mar ;20(2):87-91. PMID : 15729083 [PubMed - indexed for MEDLINE] 21 : Related Articles, Links Szegedi A, Kohnen R, Dienel A, Kieser M. Free in PMC Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St John’s wort) : randomised controlled double blind non-inferiority trial versus paroxetine. BMJ. 2005 Mar 5 ;330(7490):503. Epub 2005 Feb 11. Erratum in : BMJ. 2005 Apr 2 ;330(7494):759. dosage error in text. PMID : 15708844 [PubMed - indexed for MEDLINE] 22 : Related Articles, Links Hicks SM, Walker AF, Gallagher J, Middleton RW, Wright J. Abstract The significance of « nonsignificance » in randomized controlled studies : a discussion inspired by a double-blinded study on St. John’s wort (Hypericum perforatum L.) for premenstrual symptoms. J Altern Complement Med. 2004 Dec ;10(6):925-32. PMID : 15673985 [PubMed - indexed for MEDLINE] 23 : Related Articles, Links Uebelhack R, Gruenwald J, Graubaum HJ, Busch R. Abstract Efficacy and tolerability of Hypericum extract STW 3-VI in patients with moderate depression : a double-blind, randomized, placebo-controlled clinical trial. Adv Ther. 2004 Jul-Aug ;21(4):265-75. PMID : 15605620 [PubMed - indexed for MEDLINE] 24 : Related Articles, Links Bjerkenstedt L, Edman GV, Alken RG, Mannel M. Abstract Hypericum extract LI 160 and fluoxetine in mild to moderate depression : a randomized, placebo-controlled multi-center study in outpatients. Eur Arch Psychiatry Clin Neurosci. 2005 Feb ;255(1):40-7. Epub 2004 Nov 12. PMID : 15538592 [PubMed - indexed for MEDLINE] 25 : Related Articles, Links Zanoli P. Abstract Role of hyperforin in the pharmacological activities of St. John’s Wort. CNS Drug Rev. 2004 Fall ;10(3):203-18. Review. PMID : 15492771 [PubMed - indexed for MEDLINE] 26 : Related Articles, Links Gelenberg AJ, Shelton RC, Crits-Christoph P, Keller MB, Dunner DL, Hirschfeld RM, Thase ME, Russell JM, Lydiard RB, Gallop RJ, Todd L, Hellerstein DJ, Goodnick PJ, Keitner GI, Stahl SM, Halbreich U, Hopkins HS. Abstract The effectiveness of St. John’s Wort in major depressive disorder : a naturalistic phase 2 follow-up in which nonresponders were provided alternate medication. J Clin Psychiatry. 2004 Aug ;65(8):1114-9. PMID : 15323598 [PubMed - indexed for MEDLINE] 27 : Related Articles, Links Müller T, Mannel M, Murck H, Rahlfs VW. Free Full Text Treatment of somatoform disorders with St. John’s wort : a randomized, double-blind and placebo-controlled trial. Psychosom Med. 2004 Jul-Aug ;66(4):538-47. PMID : 15272100 [PubMed - indexed for MEDLINE] 28 : Related Articles, Links Schulte-Löbbert S, Holoubek G, Müller WE, Schubert-Zsilavecz M, Wurglics M. Abstract Comparison of the synaptosomal uptake inhibition of serotonin by St John’s wort products. J Pharm Pharmacol. 2004 Jun ;56(6):813-8. PMID : 15231048 [PubMed - indexed for MEDLINE] 29 : Related Articles, Links Kiewert C, Buchholzer ML, Hartmann J, Chatterjee SS, Klein J. Abstract Stimulation of hippocampal acetylcholine release by hyperforin, a constituent of St. John’s Wort. Neurosci Lett. 2004 Jul 8 ;364(3):195-8. PMID : 15196674 [PubMed - indexed for MEDLINE] 30 : Related Articles, Links Simbrey K, Winterhoff H, Butterweck V. Abstract Extracts of St. John’s wort and various constituents affect beta-adrenergic binding in rat frontal cortex. Life Sci. 2004 Jan 9 ;74(8):1027-38. PMID : 14672758 [PubMed - indexed for MEDLINE] 31 : Related Articles, Links Usai M, Leggio B, Grappi S, Nanni G, Gambarana C, Tolu P, Giachetti D, De Montis MG. Abstract Hypericum perforatum subspecies angustifolium shows a protective activity on the consequences of unavoidable stress exposure at lower doses than Hypericum perforatum perforatum. Pharmacopsychiatry. 2003 Nov ;36(6):283-7. PMID : 14663651 [PubMed - indexed for MEDLINE] 32 : Related Articles, Links Franklin M. Abstract Sub-chronic treatment effects of an extract of Hypericum perforatum (St. John’s Wort, Li 160) on neuroendocrine responses to the 5-T2A agonist, DOI in the rat. Pharmacopsychiatry. 2003 Jul ;36(4):161-4. PMID : 12905103 [PubMed - indexed for MEDLINE] 33 : Related Articles, Links Butterweck V, Winterhoff H, Herkenham M. Free Full Text Hyperforin-containing extracts of St John’s wort fail to alter gene transcription in brain areas involved in HPA axis control in a long-term treatment regimen in rats. Neuropsychopharmacology. 2003 Dec ;28(12):2160-8. PMID : 12865894 [PubMed - indexed for MEDLINE] 34 : Related Articles, Links Schempp CM, Windeck T, Hezel S, Simon JC. Abstract Topical treatment of atopic dermatitis with St. John’s wort cream—a randomized, placebo controlled, double blind half-side comparison. Phytomedicine. 2003 ;10 Suppl 4:31-7. PMID : 12807340 [PubMed - indexed for MEDLINE] 35 : Related Articles, Links Butterweck V, Christoffel V, Nahrstedt A, Petereit F, Spengler B, Winterhoff H. Abstract Step by step removal of hyperforin and hypericin : activity profile of different Hypericum preparations in behavioral models. Life Sci. 2003 Jun 20 ;73(5):627-39. PMID : 12770617 [PubMed - indexed for MEDLINE] 36 : Related Articles, Links Schempp CM, Hezel S, Simon JC. Abstract [Topical treatment of atopic dermatitis with Hypericum cream. A randomised, placebo-controlled, double-blind half-side comparison study] Hautarzt. 2003 Mar ;54(3):248-53. Epub 2003 Feb 18. German. PMID : 12634994 [PubMed - indexed for MEDLINE] 37 : Related Articles, Links Müller WE. Abstract Current St John’s wort research from mode of action to clinical efficacy. Pharmacol Res. 2003 Feb ;47(2):101-9. Review. PMID : 12543057 [PubMed - indexed for MEDLINE] 38 : Related Articles, Links Kasper S, Dienel A. Abstract Cluster analysis of symptoms during antidepressant treatment with Hypericum extract in mildly to moderately depressed out-patients. A meta-analysis of data from three randomized, placebo-controlled trials. Psychopharmacology (Berl). 2002 Nov ;164(3):301-8. Epub 2002 Sep 14. PMID : 12424554 [PubMed - indexed for MEDLINE] 39 : Related Articles, Links Volz HP, Murck H, Kasper S, Möller HJ. Abstract St John’s wort extract (LI 160) in somatoform disorders : results of a placebo-controlled trial. Psychopharmacology (Berl). 2002 Nov ;164(3):294-300. Epub 2002 Jul 17. Erratum in : Psychopharmacology (Berl). 2003 May ;167(3):333. PMID : 12424553 [PubMed - indexed for MEDLINE] 40 : Related Articles, Links Schulz V. Abstract Clinical trials with hypericum extracts in patients with depression—results, comparisons, conclusions for therapy with antidepressant drugs. Phytomedicine. 2002 Jul ;9(5):468-74. Review. PMID : 12222670 [PubMed - indexed for MEDLINE] 41 : Related Articles, Links Laakmann G, Jahn G, Schüle C. Abstract [Hypericum perforatum extract in treatment of mild to moderate depression. Clinical and pharmacological aspects] Nervenarzt. 2002 Jul ;73(7):600-12. German. PMID : 12212522 [PubMed - indexed for MEDLINE] 42 : Related Articles, Links Lecrubier Y, Clerc G, Didi R, Kieser M. Free Full Text Efficacy of St. John’s wort extract WS 5570 in major depression : a double-blind, placebo-controlled trial. Am J Psychiatry. 2002 Aug ;159(8):1361-6. PMID : 12153829 [PubMed - indexed for MEDLINE] 43 : Related Articles, Links Butterweck V, Nahrstedt A, Evans J, Hufeisen S, Rauser L, Savage J, Popadak B, Ernsberger P, Roth BL. Abstract In vitro receptor screening of pure constituents of St. John’s wort reveals novel interactions with a number of GPCRs. Psychopharmacology (Berl). 2002 Jul ;162(2):193-202. Epub 2002 May 9. PMID : 12110997 [PubMed - indexed for MEDLINE] 44 : Related Articles, Links Behnke K, Jensen GS, Graubaum HJ, Gruenwald J. Abstract Hypericum perforatum versus fluoxetine in the treatment of mild to moderate depression. Adv Ther. 2002 Jan-Feb ;19(1):43-52. PMID : 12008860 [PubMed - indexed for MEDLINE] 45 : Related Articles, Links Hypericum Depression Trial Study Group. Free Full Text Effect of Hypericum perforatum (St John’s wort) in major depressive disorder : a randomized controlled trial. JAMA. 2002 Apr 10 ;287(14):1807-14. PMID : 11939866 [PubMed - indexed for MEDLINE] 46 : Related Articles, Links Williamson EM. Abstract Synergy and other interactions in phytomedicines. Phytomedicine. 2001 Sep ;8(5):401-9. Review. PMID : 11695885 [PubMed - indexed for MEDLINE] 47 : Related Articles, Links Boniel T, Dannon P. Abstract [The safety of herbal medicines in the psychiatric practice] Harefuah. 2001 Aug ;140(8):780-3, 805. Review. Hebrew. PMID : 11547487 [PubMed - indexed for MEDLINE] 48 : Related Articles, Links Butterweck V, Winterhoff H, Herkenham M. Free Full Text St John’s wort, hypericin, and imipramine : a comparative analysis of mRNA levels in brain areas involved in HPA axis control following short-term and long-term administration in normal and stressed rats. Mol Psychiatry. 2001 Sep ;6(5):547-64. PMID : 11526469 [PubMed - indexed for MEDLINE] 49 : Related Articles, Links Kientsch U, Bürgi S, Ruedeberg C, Probst S, Honegger UE. Abstract St. John’s wort extract Ze 117 (Hypericum perforatum) inhibits norepinephrine and serotonin uptake into rat brain slices and reduces 3-adrenoceptor numbers on cultured rat brain cells. Pharmacopsychiatry. 2001 Jul ;34 Suppl 1:S56-60. PMID : 11518078 [PubMed - indexed for MEDLINE] 50 : Related Articles, Links Kasper S. Abstract Hypericum perforatum—a review of clinical studies. Pharmacopsychiatry. 2001 Jul ;34 Suppl 1:S51-5. Review. PMID : 11518077 [PubMed - indexed for MEDLINE] 51 : Related Articles, Links Käufeler R, Meier B, Brattström A. No Abstract Efficacy and tolerability of Ze 117 St. John’s wort extract in comparison with placebo, imipramine and fluoxetine for the treatment of mild to moderate depression according to ICD-10. An overview. Pharmacopsychiatry. 2001 Jul ;34 Suppl 1:S49-50. Review. No abstract available. PMID : 11518076 [PubMed - indexed for MEDLINE] 52 : Related Articles, Links Gambarana C, Tolu PL, Masi F, Rinaldi M, Giachetti D, Morazzoni P, De Montis MG. Abstract A study of the antidepressant activity of Hypericum perforatum on animal models. Pharmacopsychiatry. 2001 Jul ;34 Suppl 1:S42-4. PMID : 11518074 [PubMed - indexed for MEDLINE] 53 : Related Articles, Links Friede M, Henneicke von Zepelin HH, Freudenstein J. Abstract Differential therapy of mild to moderate depressive episodes (ICD-10 F 32.0 ; F 32.1) with St. John’s wort. Pharmacopsychiatry. 2001 Jul ;34 Suppl 1:S38-41. PMID : 11518073 [PubMed - indexed for MEDLINE] 54 : Related Articles, Links Butterweck V, Korte B, Winterhoff H. Abstract Pharmacological and endocrine effects of Hypericum perforatum and hypericin after repeated treatment. Pharmacopsychiatry. 2001 Jul ;34 Suppl 1:S2-7. PMID : 11518068 [PubMed - indexed for MEDLINE] 55 : Related Articles, Links Sarrell EM, Mandelberg A, Cohen HA. Free Full Text Efficacy of naturopathic extracts in the management of ear pain associated with acute otitis media. Arch Pediatr Adolesc Med. 2001 Jul ;155(7):796-9. PMID : 11434846 [PubMed - indexed for MEDLINE] 56 : Related Articles, Links Kalb R, Trautmann-Sponsel RD, Kieser M. Abstract Efficacy and tolerability of hypericum extract WS 5572 versus placebo in mildly to moderately depressed patients. A randomized double-blind multicenter clinical trial. Pharmacopsychiatry. 2001 May ;34(3):96-103. PMID : 11434406 [PubMed - indexed for MEDLINE] 57 : Related Articles, Links Hübner WD, Kirste T. Abstract Experience with St John’s Wort (Hypericum perforatum) in children under 12 years with symptoms of depression and psychovegetative disturbances. Phytother Res. 2001 Jun ;15(4):367-70. PMID : 11406865 [PubMed - indexed for MEDLINE] 58 : Related Articles, Links Shelton RC, Keller MB, Gelenberg A, Dunner DL, Hirschfeld R, Thase ME, Russell J, Lydiard RB, Crits-Cristoph P, Gallop R, Todd L, Hellerstein D, Goodnick P, Keitner G, Stahl SM, Halbreich U. Free Full Text Effectiveness of St John’s wort in major depression : a randomized controlled trial. JAMA. 2001 Apr 18 ;285(15):1978-86. PMID : 11308434 [PubMed - indexed for MEDLINE] 59 : Related Articles, Links Kasper S, Schulz V. Abstract [St. Johns wort extract as plant antidepressant] Schweiz Rundsch Med Prax. 2000 Dec 21 ;89(51-52):2169-77. Review. German. PMID : 11197298 [PubMed - indexed for MEDLINE] 60 : Related Articles, Links Dürr D, Stieger B, Kullak-Ublick GA, Rentsch KM, Steinert HC, Meier PJ, Fattinger K. Abstract St John’s Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4. Clin Pharmacol Ther. 2000 Dec ;68(6):598-604. PMID : 11180019 [PubMed - indexed for MEDLINE] 61 : Related Articles, Links Schulte PF. Abstract [Saint John’s Wort as an antidepressant] Ned Tijdschr Geneeskd. 2000 Sep 16 ;144(38):1820-5. Review. Dutch. PMID : 11020834 [PubMed - indexed for MEDLINE] 62 : Related Articles, Links Woelk H. Free in PMC Comparison of St John’s wort and imipramine for treating depression : randomised controlled trial. BMJ. 2000 Sep 2 ;321(7260):536-9. PMID : 10968813 [PubMed - indexed for MEDLINE] 63 : Related Articles, Links Grube B, Walper A, Wheatley D. Abstract St. John’s Wort extract : efficacy for menopausal symptoms of psychological origin. Adv Ther. 1999 Jul-Aug ;16(4):177-86. PMID : 10623319 [PubMed - indexed for MEDLINE] 64 : Related Articles, Links Philipp M, Kohnen R, Hiller KO. Free in PMC Hypericum extract versus imipramine or placebo in patients with moderate depression : randomised multicentre study of treatment for eight weeks. BMJ. 1999 Dec 11 ;319(7224):1534-8. Erratum in : BMJ 2000 Feb 5 ;320(7231):361. PMID : 10591711 [PubMed - indexed for MEDLINE] 65 : Related Articles, Links Holsboer-Trachsler E, Vanoni C. Abstract [Clinical efficacy and tolerance of the hypericum special extract LI 160 in depressive disorders—a drug monitoring study] Schweiz Rundsch Med Prax. 1999 Sep 9 ;88(37):1475-80. German. PMID : 10522458 [PubMed - indexed for MEDLINE] 66 : Related Articles, Links Kasper S, Schulz V. Abstract [High dose St. John’s wort extract as a phytogenic antidepressant] Wien Med Wochenschr. 1999 ;149(8-10):191-6. Review. German. PMID : 10483679 [PubMed - indexed for MEDLINE] 67 : Related Articles, Links Nathan P. Abstract The experimental and clinical pharmacology of St John’s Wort (Hypericum perforatum L.). Mol Psychiatry. 1999 Jul ;4(4):333-8. Review. PMID : 10483049 [PubMed - indexed for MEDLINE] 68 : Related Articles, Links Lenoir S, Degenring FH, Saller R. Abstract A double-blind randomised trial to investigate three different concentrations of a standardised fresh plant extract obtained from the shoot tips of Hypericum perforatum L. Phytomedicine. 1999 Jul ;6(3):141-6. PMID : 10439477 [PubMed - indexed for MEDLINE] 69 : Related Articles, Links Gambarana C, Ghiglieri O, Tolu P, De Montis MG, Giachetti D, Bombardelli E, Tagliamonte A. Free Full Text Efficacy of an Hypericum perforatum (St. John’s wort) extract in preventing and reverting a condition of escape deficit in rats. Neuropsychopharmacology. 1999 Aug ;21(2):247-57. PMID : 10432473 [PubMed - indexed for MEDLINE] 70 : Related Articles, Links Harrer G, Schmidt U, Kuhn U, Biller A. Abstract Comparison of equivalence between the St. John’s wort extract LoHyp-57 and fluoxetine. Arzneimittelforschung. 1999 Apr ;49(4):289-96. PMID : 10337446 [PubMed - indexed for MEDLINE] 71 : Related Articles, Links Cupp MJ. Free Full Text Herbal remedies : adverse effects and drug interactions. Am Fam Physician. 1999 Mar 1 ;59(5):1239-45. Review. PMID : 10088878 [PubMed - indexed for MEDLINE] 72 : Related Articles, Links Hippius H. Abstract St John’s Wort (Hypericum perforatum)—a herbal antidepressant. Curr Med Res Opin. 1998 ;14(3):171-84. PMID : 9787983 [PubMed - indexed for MEDLINE] 73 : Related Articles, Links Zink T, Chaffin J. Free Full Text Herbal ’health’ products : what family physicians need to know. Am Fam Physician. 1998 Oct 1 ;58(5):1133-40. Review. Erratum in : Am Fam Physician 1999 Feb 1 ;59(3):540. PMID : 9787279 [PubMed - indexed for MEDLINE] 74 : Related Articles, Links Laakmann G, Schüle C, Baghai T, Kieser M. Abstract St. John’s wort in mild to moderate depression : the relevance of hyperforin for the clinical efficacy. Pharmacopsychiatry. 1998 Jun ;31 Suppl 1:54-9. PMID : 9684948 [PubMed - indexed for MEDLINE] 75 : Related Articles, Links Schellenberg R, Sauer S, Dimpfel W. Abstract Pharmacodynamic effects of two different hypericum extracts in healthy volunteers measured by quantitative EEG. Pharmacopsychiatry. 1998 Jun ;31 Suppl 1:44-53. PMID : 9684947 [PubMed - indexed for MEDLINE] 76 : Related Articles, Links Dimpfel W, Schober F, Mannel M. Abstract Effects of a methanolic extract and a hyperforin-enriched CO2 extract of St. John’s Wort (Hypericum perforatum) on intracerebral field potentials in the freely moving rat (Tele-Stereo-EEG). Pharmacopsychiatry. 1998 Jun ;31 Suppl 1:30-5. PMID : 9684945 [PubMed - indexed for MEDLINE] 77 : Related Articles, Links Miller AL. Free Full Text St. John’s Wort (Hypericum perforatum) : clinical effects on depression and other conditions. Altern Med Rev. 1998 Feb ;3(1):18-26. Review. PMID : 9600023 [PubMed - indexed for MEDLINE] 78 : Related Articles, Links Kurth H, Spreemann R. Abstract Phytochemical characterization of various St. John’s Wort extracts. Adv Ther. 1998 Mar-Apr ;15(2):117-28. PMID : 10180998 [PubMed - indexed for MEDLINE] 79 : Related Articles, Links Mueller BM. Abstract St. John’s Wort for depressive disorders : results of an outpatient study with the Hypericum preparation HYP 811. Adv Ther. 1998 Mar-Apr ;15(2):109-16. PMID : 10180997 [PubMed - indexed for MEDLINE] 80 : Related Articles, Links Vorbach EU, Arnoldt KH, Hübner WD. Abstract Efficacy and tolerability of St. John’s wort extract LI 160 versus imipramine in patients with severe depressive episodes according to ICD-10. Pharmacopsychiatry. 1997 Sep ;30 Suppl 2:81-5. PMID : 9342765 [PubMed - indexed for MEDLINE] 81 : Related Articles, Links Wheatley D. Abstract LI 160, an extract of St. John’s wort, versus amitriptyline in mildly to moderately depressed outpatients—a controlled 6-week clinical trial. Pharmacopsychiatry. 1997 Sep ;30 Suppl 2:77-80. PMID : 9342764 [PubMed - indexed for MEDLINE] 82 : Related Articles, Links Volz HP. Abstract Controlled clinical trials of hypericum extracts in depressed patients—an overview. Pharmacopsychiatry. 1997 Sep ;30 Suppl 2:72-6. Review. PMID : 9342763 [PubMed - indexed for MEDLINE] 83 : Related Articles, Links Schmidt U, Sommer H. Abstract [St. John’s wort extract in the ambulatory therapy of depression. Attention and reaction ability are preserved] Fortschr Med. 1993 Jul 10 ;111(19):339-42. German. PMID : 8370566 [PubMed - indexed for MEDLINE]


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